An Architecture for a Wide Area Distributed System

this paper is part of the Globe Project (Globe stands for GLobal Object Based Environment) . The goal of this project is the design and implementation of a wide area distributed system that provides a convenient programming abstraction and full transparency. The main contribution of this paper is the description of a new system for distributed shared objects. In contrast to other systems, the implementation of distribution, consistency, and replication of state is completely encapsulated in a distributed shared object. This allows for object-specific solutions, and provides the right mechanism for building efficient and truly scalable systems. 2 Problems to be Solve

Communication in GLOBE: An Object-Based Worldwide Operating System

Current paradigms for interprocess communication are not sufficient to describe the exchange of information at an adequate level of abstraction. They are either too lowlevel, or their implementations cannot meet performance requirements. As an alternative, we propose distributed shared objects as a unifying concept. These objects offer user-defined operations on shared state, but allow for efficient implementations through replication and distribution of state. In contrast to other object-based models, these implementation aspects are completely hidden from applications. 1 Introduction In the 1960s and 1970s, the computing universe was dominated by mainframes and minicomputers that ran batch and timesharing operating systems. Typical examples of these systems were OS/360 and UNIX. These system were primarily concerned with the efficient and secure sharing of the resources of a single machine among many competing users. In the 1980s, personal computers became popular. These machines h..

Distributed Shared Objects as a Communication Paradigm

Abstract. Current paradigms for interprocess communication are not sufficient to describe the exchange of information at an adequate level of abstraction. They are either too low-level, or their implementations cannot meet performance requirements. As an alternative, we propose distributed shared objects as a unifying concept. These objects offer user-defined operations on shared state, but allow for efficient implementations through replication and distribution of state. In contrast to other object-based models, these implementation aspects are completely hidden from applications.

Genes and the ageing muscle: a review on genetic association studies

Western populations are living longer. Ageing decline in muscle mass and strength (i.e. sarcopenia) is becoming a growing public health problem, as it contributes to the decreased capacity for independent living. It is thus important to determine those genetic factors that interact with ageing and thus modulate functional capacity and skeletal muscle phenotypes in older people. It would be also clinically relevant to identify 'unfavourable' genotypes associated with accelerated sarcopenia. In this review, we summarized published information on the potential associations between some genetic polymorphisms and muscle phenotypes in older people. A special emphasis was placed on those candidate polymorphisms that have been more extensively studied, i.e. angiotensin-converting enzyme (ACE) gene I/D, α-actinin-3 (ACTN3) R577X, and myostatin (MSTN) K153R, among others. Although previous heritability studies have indicated that there is an important genetic contribution to individual variability in muscle phenotypes among old people, published data on specific gene variants are controversial. The ACTN3 R577X polymorphism could influence muscle function in old women, yet there is controversy with regards to which allele (R or X) might play a 'favourable' role. Though more research is needed, up-to-date MSTN genotype is possibly the strongest candidate to explain variance among muscle phenotypes in the elderly. Future studies should take into account the association between muscle phenotypes in this population and complex gene-gene and gene-environment interactions.3.445 JCR (2013) Q1, 11/49 Geriatrics & gerontologyUE